Where do I start!?!?
Currently DM for Team Melee on Saturdays. Of the 4 PCs, they possessed, at 4th level, approximately 2 Ranged attack options, one of which was a SINGLE ALCHEMIST FIRE and the other was the Vampire's Weakest possible action! At this point, I said EFF this, Homebrew Button is pressed in the CB and EVERYONE is getting a Free Ranged At-Will For Christmas in Mid October!!!!
Other Current Campaign I run is Online using Maptool. Team is slightly better. Slightly:P Been fun actually. Major events include the Boss of Heroic Tier being finished off by the Fighter's Pet Owlbear, The Bard's Majestic Word Quotes(Always different, Always Screwed Up and Funny as anything!), Insane Tiefling Star Pact Warlock naming the Female Minotaur Fighter "Cowthulu", And the Tale of the "Chicken-Chaser", their first Magic Weapon! This game must be awesome, seeing as one of the players wakes up at 2:30AM local time to play in it!
As for older games, my First ever Campaign earned the name "Brutal Adventures", mainly due to the Death and Reincarnation of the Party Barbarian. "Unglar, Half-Orc Barbarian" became "Unglar, Brown Bear Barbarian of Campaign Unbalancing"TM! Anything that was a Challenge for Unglar was Was too much of a Challenge for the rest of the Party! And Of course Unglar went Straight for the weaklings meant for the rest of the party, leaving the Big Bad Evil Guy for the weaker PCs to get nearly slaughtered by:P
That's some of the more memorable events I can recall at the moment.